Does Topical Finasteride Work?
Topical finasteride is usually compounded with minoxidil. According to the experiences of several hair loss clinics, a topical solution with both finasteride and minoxidil offers similar or even better results than taking minoxidil together with an oral finasteride pill (1mg).
In the 7th World Congress on Hair Research, a Dutch research group reported the effect of topical and oral administration of finasteride on DHT levels in the scalp and serum. The results are shown in the Table below. It shows that 1 mg of topical finasteride (once a day) controls DHT level in the scalp more effectively than 1 ml of oral finasteride. It reduces DHT level in the scalp by 71% while the oral finasteride only decreases the level by 51%. Meanwhile, both administrations decrease DHT level in serum by almost the same degree (~70%). This is understandable, as the topical finasteride is applied to the scalp directly and therefore the finasteride concentration in the scalp is expected to be higher than when the same amount of finasteride is administrated orally. This study also suggests that if you get a side effect from oral finasteride, you will most likely get a side effect from topical finasteride.
|DHT level change in the scalp (decreased by)||DHT level change in serum (decreased by)|
|1 mg topical finasteride||Once a day (q.d) (N=6)||71%||69.3–74.0%|
|Twice a day (b.i.d)(each time is 0.5mg) (N=6)||47%||67.6–80.4%|
|Finasteride oral pill||Once a day (N=6)||51%||69.7–76.1%|
(see the details of this study below, study 1)
There are some other studies that show a similar conclusion. In 2012, a Thailand group compared the efficacy and safety of the 24 weeks application of 3% minoxidil lotion (MNX) versus combined 3% minoxidil and 0.1% finasteride lotion (MFX) in men with AGA. Results show the MFX group had significantly greater improvement than the MNX group in the amount of hair regrowth, and no side effect was reported (see the details of this study below, study 2).
In 2009, an Iranian group compared the therapeutic effects of topical finasteride gel and tablet in treatment of male pattern hair loss, and found that the therapeutic effects of both finasteride gel and finasteride tablet were relatively similar to each other ( (see the details of this study below, study 3).
Interestingly, the results also shows that when you applied 0.5 mg topical finasteride twice a day (total amount is 1mg) it is actually less effective in controlling DHT level in the scalp, compared to applying 1mg of topical finasteride once a day. The former decrease the DHT level in the scalp by 47%, while the latter by 71%.
Topical Finasteride Results:
You can view the topical finasteride results from our customers on the testimonial page. We have a lot of customers who enjoyed great success that they didn't have when not using topical finasteride. As one customer writes in his testimonial "I have tried numerous different hair regrowth products, Minoxidilmax's topical finasteride (Dualgen-15 NO PG plus) is the only product that did stop my hair loss and grew my hair back. Topical finasteride may not be for everyone. But if you have tried minoxidil and din't receive good results, you should definitely put on topical finasteride. It is much more effective than minoxidil alone, and it is more cost effective than taking oral finasteride.". See the testimonial page here.
Topical Side Effects:
M Caserini1, R Palmieri1, M Radicioni2 and E Terragni2 1Polichem S.A., Lugano, Switzerland and 2Cross Research S.A., Arzo, Switzerland
A new proprietary topical formulation, P-3074, containing finasteride 0.25% as active ingredient and hydroxypropyl-chitosan (HPCH) as film-forming agent, was developed for androgenetic alopecia. The present study was aimed at investigating the pharmacodynamic profile of finasteride in terms of dihydrotestosterone (DHT) concentrations in the scalp and in serum after multiple topical application of P-3074 or oral finasteride intake in subjects with androgenetic alopecia. Eighteen healthy men were randomly allocated to P-3074 or oral treatment after providing written informed consent. Twelve volunteers applied P-3074 topical solution for 7 days: six subjects once daily (o.d.) in the morning and the others twice daily (b.i.d.) in the morning and in the evening. The third group of six volunteers was administered 1 mg oral finasteride once daily in the morning for 1 week. Scalp (vertex) biopsies were collected at baseline and 6 hours after last dose administration, while serum samples were collected at baseline, before last administration, and 6 and 12 hours after the last multiple dose. A marked decrease in scalp DHT levels was observed: by 47.22% with P-3074 b.i.d., from 1.91 (±0.54) to 1.01 ng ml−1 (±0.39), by 71.20% with P-3074 o.d., from 1.52 (±0.41) to 0.44 ng ml−1 (±0.08), and by 51.11% with the oral formulation, from 1.39 (±0.25) to 0.68 ng ml−1 (±0.34). Serum DHT was reduced by 69.3–74.0% with P-3074 b.i.d., 67.6–80.4% with P-3074 o.d., and 69.7–76.1%with the oral formulation. These results showed a similar inhibition of serum DHT after 1 week of finasteride administration with the three dose regimens and were consistent with the results obtained in a previous P-3074 PK study. These findings show that DHT concentration in the scalp, after 7-day treatment course of P-3074 o.d., was more reduced (about 40%) than after 1 mg oral finasteride administration for the same treatment period.
Finasteride Side Effects?
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