Tugain 10 for Hair Loss and Beard Growth
Tugain 10

Introduction

Tugain 10 is a solution which contains minoxidil and is primarily used for the treatment of androgenetic alopecia (male pattern baldness). Tugain is produced by Cipla, an Indian multinational pharmaceutical and biotechnological company which develops a variety of medicines for respiratory, rheumatological, cardiovascular and mood disorders. The primary ingredient in Tugain 10 is minoxidil – a potent vasodilator which has been used in the treatment of hair growth disorders in men and women.

Originally developed in the 1970s for the treatment of hypertension, the minoxidil in Tugain 10 was observed to cause abnormal hair growth as an unintended side effect. The chemical within minoxidil (2,4-diamino-6 piperidino-pyrimidine-3-oxide) causes potassium channels in the smooth muscle cells around the arteries supplying the hair follicles to dilate. This dilation of the vessels results in a better blood-flow to the hair follicles, resulting in faster and more robust growth. The Tugain range consists of liquid as well as foam preparations, each with varying levels of strength – 2%, 5% and 10%. These strengths reflect the concentration of minoxidil within the respective preparations.

 

 

The above figures reflect the range of products in the Tugain series. Tugain 2, 5 and 10 each have varying concentrations of minoxidil (2%, 5% and 10% respectively). Furthermore, Tugain 2 and Tugain 5 have even more absolute alcohol than Tugain 10.

Tugain 2

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Minoxidil 2% w/v

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Absolute alcohol 63% v/v

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Propylene Glycol – 15% v/v

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Purified water – 20% w/v

Tugain 5

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Minoxidil – 5% w/v

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Absolute alcohol 30% v/v

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Propylene Glycol – 35% v/v

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Purified water – 30% w/v

The reason that Tugain products come in different strengths, is because minoxidil is associated with some side-effects which are dose-dependent. These include, but are not limited to, chest pain, palpitations, weight-gain, headache, flushing and peripheral limb swelling. Hence, patients who have elevated blood pressure or documented heart disease may be better suited for Tugain 2 or 5.

 

 

Instructions for Use

The liquid preparation of Tugain requires the user to do the following:

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Remove the large outer cap of the bottle, and then remove the inner cap

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Insert the dropper applicator into the bottle and squeeze the rubber bulb. Release the bulb, allowing the solution to fill up to the 1 mL mark

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Gradually pour the solution from the dropper onto the centre of the area where the hair is thin

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Spread evenly with fingertips. To prevent the solution from running off the scalp, apply a small amount at a time

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Apply 1 ml of minoxidil topical solution twice daily at 12-hour intervals to the scalp

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The total daily application dose should not exceed 2 ml

 

The foam preparation of Tugain requires the user to do the following:

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Apply half a capful of foam twice daily at 12-hour intervals to the scalp

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Begin at the centre of the affected area and spread the foam out to cover the entire affected area

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Foam should be allowed to remain on scalp for 4 hours prior to washing

Ingredients of Tugain 10

As previously iterated, the main ingredient in Tugain 10 is minoxidil, a potent vasodilator of the vessels which supply blood to the hair follicles. However, there is one other ingredient in the Tugain series which consumers must be aware of – absolute alcohol. Absolute alcohol is an ingredient that is deliberately added to Tugain 10 for its antimicrobial activity. It is also added to the product in order to extend its shelf life. Indeed, the shelf life of products in the Tugain series (e.g. Tugain 2, Tugain 5 and Tugain 10) is about 18 months. Despite these product benefits, absolute alcohol confers no benefits to the user. Research has conclusively demonstrated the harms of direct alcohol exposure to the skin as well as to the scalp. Although ethanol (a form of alcohol) enhances the skin penetration of active ingredients such as minoxidil, it also results in contact dermatitis (inflammation of the skin) as well as skin irritation. Users may experience itchiness, redness, flaking and even pain of the scalp and skin after applying the Tugain liquid/foam. Users who have a skin sensitivity or allergy to alcohol should absolutely avoid using Tugain. The other ingredients in Tugain 10 are propylene glycol and water. Propylene glycol is a humectant (hydrating) and delivery ingredient used in cosmetics and helps the minoxidil component of Tugain 10 penetrate into the skin.

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Absolute Alcohol – 40% v/v

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Minoxidil – 10% w/v

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Propylene Glycol – 20% v/v

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Purified water – 30% w/v

 

In contrast to the liquid product, the foam product of Tugain 10 contains different ingredients.

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Absolute Alcohol

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Stearyl Alcohol

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Minoxidil

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Butylhydroxytoluene (BHT)

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Lactic acid

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Citric acid

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Glycerol anhydrous

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Polysorbate 60

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Aeropin 70

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Purified water

Unlike Tugain 10, Dualgen-10 which we offer has much safer ingredients. Dualgen-10 contains the active ingredient minoxidil together with azelaic acid, retinol and caffeine. There is also the addition of our proprietary blend – ABN complex, which contains adenosine, biotin and niacinamide. As Dualgen-10 is free of absolute alcohol, this alternative is a better choice for those who wish to preserve the health of the scalp and skin while achieving impressive hair growth results.

Beard & Eyebrow Growth

The scientific evidence to date is supportive of the use of minoxidil for androgenetic alopecia. But what about beard growth? Does Tugain 10 work for men with sparse facial hair or thinning eyebrows? A Chinese study in 2016 studied 46 men who were aged between 20 to 60 years old. They were instructed to apply just 0.5ml of Minoxidil on their chin and jaw-line twice daily. Over 16 weeks, the men were assessed quarterly and hair counts as well as diameters were measured, in addition to photographs which were subjectively scored by physicians. The results showed that the mean change in hair count significantly increased in the Minoxidil group as opposed to the placebo (dummy) group

[1] . However, no change in hair diameter was found between the two groups. So far, this is the only study which has evaluated beard growth in men who use minoxidil. In regard to eyebrow hair growth, no evidence has been reported thus far. Nevertheless, there is plenty of anecdotal (experience-based) evidence and reports cited on the World Wide Web by men who have used minoxidil to achieve impressive facial hair growth.

Dualgen-10

As previously mentioned, Dualgen-10 is free of harmful absolute alcohol. In fact, Dualgen-10 has significant advantages over Tugain products. First, Dualgen-10 has additional ingredients which work synergistically with minoxidil to maximise hair growth. Adenosine, biotin and niacinamide have all been validated scientifically to increase hair growth and hair density

[2] . Dualgen-10 also contains azelaic acid which is a potent DHT (dihydrotestosterone) inhibitor which has been shown to be effective in the treatment of alopecia areata [3] . Furthermore, azelaic acid has the added advantage of being anti-inflammatory in nature and has been demonstrated to be safe and well tolerated [4] . Yet another advantage of Dualgen-10 is that it is prepared in a liquid formulation as opposed to a foam formulation. Hence, the active ingredients in Dualgen-10 are not dispersed over a wide surface area and instead are directly concentrated upon the applied area. This is because a foam formulation mixes the active ingredients with air and surfactants to produce a cloudy and bubbly material. Although this may make it easier for the user to apply the ingredients to the skin, it results in a weaker effect. Dualgen-10 also contains retinol and caffeine, both safe ingredients which have been documented to support hair growth and work synergistically with minoxidil to enhance its overall effect [5, 6] . Additionally, Dualgen-10 has a shelf life of three years. In contrast, Tugaine-10 has a shelf life of only 18 months.

 

 

Instructions for Use – Dualgen-10

Dualgen-10 is recommended for use twice daily, eight hours apart.

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Ensure scalp is dry prior to use

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Remove the large outer cap of the bottle, and then remove the inner cap

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Insert the dropper applicator into the bottle and squeeze the rubber bulb. Release the bulb, allowing the solution to fill up to the 1 mL mark

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Gradually pour the solution from the dropper onto the centre of the area where the hair is thin

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Spread evenly with fingertips. To prevent the solution from running off the scalp, apply a small amount at a time

Conclusion

Although Tugain 10 contains a potent active ingredient – minoxidil, it is significantly limited in view of its lack of additional beneficial compounds as well as its inclusion of absolute alcohol which may be harmful. Dualgen-10 represents a better alternative as it solely comes prepared as a liquid formulation and includes caffeine, retinal and ABN complex for maximal synergy with minoxidil.

 

 

References

1.            Ingprasert, S., et al., Efficacy and safety of minoxidil 3% lotion for beard enhancement: A randomized, double-masked, placebo-controlled study. J Dermatol, 2016. 43(8): p. 968-9.

2.            Watanabe, Y., et al., Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia. Int J Cosmet Sci, 2015. 37(6): p. 579-87.

3.            Sasmaz, S. and O. Arican, Comparison of azelaic acid and anthralin for the therapy of patchy alopecia areata: a pilot study. Am J Clin Dermatol, 2005. 6(6): p. 403-6.

4.            Fitton, A. and K.L. Goa, Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs, 1991. 41(5): p. 780-98.

5.            Yoo, H.G., et al., The additive effects of minoxidil and retinol on human hair growth in vitro. Biol Pharm Bull, 2007. 30(1): p. 21-6.

6.            Bansal, M., K. Manchanda, and S.S. Pandey, Role of caffeine in the management of androgenetic alopecia. International journal of trichology, 2012. 4(3): p. 185-186.

 

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