PyriPure (0.5% Pyrilutamide Solution)
Price
$105.00

$1.75 per milliliter (ml)

Option
PRODUCT DESCRIPTION
  •  

    Pyrilutamide solution in a propylene glycol and ethanol vehicle. 

    Concentration: 0.5% (5 mg/ml) 

    Size:  60 ml.

    Purity of Raw Material:  >99% pure. Every batch of Pyrilutamide, also called KX-826, is tested and confirmed by a 3rd party prior to usage. 

    Product comes with a calibrated dropper.

    PyriPure is for research purpose only. Not for human consumption. 

     

     

     

     

PRODUCT IMAGE
  • pyrilutamide

FREQUENTLY ASKED QUESTIONS
  • How do you test the purity of the product?

    The raw material pyrilutamide (aka, KX-826) used in PyriPure was confirmed to be >99% pure by a professional testing lab. See reports here.

     

    What is pyrilutamide? 

    KX-826, also known as Pyrilutamide or Pyri, is a new chemical developed by Suzhou Kintor Pharmaceuticals, a Chinese biotechnology company focusing on androgen receptor-related disease areas without effective treatments. These include conditions such as prostate, breast, and liver cancer as well as hair loss. Pyrilutamide is undergoing Phase II and III trials in China and the United States. Its structure is shown below in comparison to that of RU58841. As you cans see, they have very similar structures. The different parts are highlighted by red bonds.

     

     

    How should the product be stored?

    The 0.5% pyrilutamide solution is in an air and light tight bottle. The bottle should be stored in a cool environment such as a fridge.

     

    What is the shelf life of the product?

    The pyrilutamide solution is freshly made from pure pyrilutamide powder. It is stable for at least one year after being shipped. 

      

     

    How does pyrilutamide work to treat hair loss?

    Pyrilutamide is a non-steroidal anti-androgen (NSAA). NSAAs work by blocking testosterone and DHT from binding with the androgen receptor in the follicle. This is different from GT20029, another compound developed by Suzhou Kintor Pharmaceuticals for the treatment of hair loss and acne. GT20029 (AR-PROTAC) works by degrading androgen receptors. 

    DHT is the key androgen that causes hairs to thin.

    In the scalp, testosterone is converted into Dihydrotestosterone (DHT) by an enzyme called 5-alpha reductase. DHT strongly binds to hormone receptors in the hair follicle and activates genes responsible for the shortening of the growth phase. As this process is replicated over the scalp, hair coverage thins out usually over the crown, temples, and frontal areas. Pyrilutamide is an antagonist of the androgen receptor (AR). It binds to hair folicle AR to prevent DHT from binding to it. 

     

     

     

    Does Pyrilutamide work for hair loss?

    Whether a topical NSAA like Pyrilutamide works for hair loss and has an acceptable side effect profile is yet to be confirmed.

    What does the evidence say?

    Aside from press releases, no results from the clinical trials of Pyrilutamide have been made public. Pyrilutamide is currently undergoing phase II trials for male patients in the US and female patients in China. The manufacturer, Kintor, announced that an earlier phase II trial was completed in September 2021 and that efficacy and safety endpoints had been met.

    A larger scale, phase III trial is currently underway. According to Kintor Pharmaceuticals, the trial will be carried out across 26 hospitals in China and will involve more than 400 patients. Enrolment for the trial was due to be completed last month with the trial due for completion at the end of 2022. The trial will aim to assess the change from baseline in non-vellus target area hair count (TAHC) after 6 months of treatment.

     As Phase III trials typically involve large numbers of patients, the results will likely give us a better idea of how safe and effective (or not) pyrilutamide is.

     

    The leaked pyrilutamide results

    The below image is reportedly a leaked slide of data from a presentation of the completed phase II trial. The left table shows the characteristics of the study recruits, while the box on the right shows some of the results of how effective the KX-826 is versus a placebo.

    We can see that it was tested at two different concentrations, one group of 27 patients used 0.25% twice a day, while another group of 30 was given 0.5% twice a day (BID). 19 People were given a placebo, likely a dummy serum.

    The total area hair count (TAHC) was taken before the treatment started and again 6 months later. On average, in the area tested, study participants in the 0.5% group had an average of 22.73 extra hairs after treatment than before, while the 0.25% had 14.75 extra hairs after treatment.

    At first glance, both doses seem to have a positive effect on hair growth.

    kintor pharma kx826 pyrilutamide phase 2 results

     

     

    The nitty-gritty of the numbers.

    The P-values below the TAHC count, are the results of mathematical tests of statistical significance. Researchers use these tests to work out whether their results are down to a genuine effect, or due to pure chance. A value of <0.05 is generally taken as the cut-off for a positive effect. A P-value of <0.024 suggests that the 0.5% serum is significantly better than the placebo, but with a P-value of 0.175, the 0.25% serum is not.

     

    How to make Pyrilutamide solution

    If one likes to make a solution, a propylene glycol and ethanol vehicle would be a suitable vehicle for this material. Water should be avoided, due to the nitrile group (-C≡N) that can be hydrolyzed in both acidic and basic enviorment in presence of water.

     

    Pyrilutamide Stability and Storage

    Pyrilutamide solution should be stored away from sunlight, in a dark area or room at 0 - 4 C.  For short-term storage, 1 to 2 months, it can be stored at room temperature. 

    Pyrilutamide power is expected to be stable for several years when stored in a freezer. 

     

     

     

    Pyrilutamide vs Existing treatments for hair loss

    The two most common treatments for androgenetic alopecia are finasteride and minoxidil, both of which have good evidence behind them[1]. Each targets different aspects of the hair loss process.

    Pyrilutamide vs Oral Finasteride, Dutasteride

    Finasteride (Propecia or Proscar) is an oral 5 alpha-reductase inhibitor, which means that it blocks the conversion of testosterone to DHT and has been shown to decrease scalp DHT levels by up to 60%[2]. The most common side effect of Finasteride is sexual dysfunction – problems getting or maintaining an erection, delayed ejaculation and decreased libido, affecting around 1.5% of men [3,4].

    Dutasteride is more potent, reducing the levels of DHT in the blood by around 94% [5]. Dutasteride is normally used for benign prostatic hyperplasia but has been used off-label for androgenetic alopecia. Evidence suggests that dutasteride is also effective for treating hair loss [6], but less information is known about its safety and side effects when used off-label. Sexual side effects of dutasteride seem to be more common than fin [7].

     

    Pyrilutamide vs Minoxidil

    Minoxidil works by dilating blood vessels on the scalp. Its mechanism isn’t fully understood, but it is thought that by increasing blood flow to the hair follicles, the growth phase is prolonged and the production of thin, vellus hairs is decreased[8].  Minoxidil is safe and has few side effects aside from localized irritation of the skin[9].

     

    Pyrilutamide vs other Androgen antagonists

    Pyrilutamide is not the first androgen receptor antagonist that has been used in the treatment of hair loss. RU-58841 is a non-steroidal anti-androgen (NSAA) while CB-0301 is a steroidal anti-androgen. Topical anti-androgens may have a preferable side effect profile than 5-alpha reductase inhibitors such as finasteride and dutasteride because the former do not affect DHT level while the latter does.

    Pyrilutamide vs RU58841

    Like Pyrilutamide, RU-58841 (also known as PSK-3841 or HMR-3841) is an NSAA.  RU58841 binds to the androgen receptor with an equivalent affinity to testosterone and blocks DHT and testosterone from binding to the androgen receptor.

    This compound was previously under investigation by the manufacturer, ProStrakan, a Scottish Pharmaceutical company, and phase I and II trials were completed, but no data from these trials was published and clinical trials have halted since 2007.

    Some people who can't use finasteride have been using RU58841 as alternative. Some received positive results, while some didn't and hope Pyrilutamide will be the savior.  Yet, it is still not known whether those who got side effects from finasteride and/or RU 58841 will have no side effects from this new product.

     

     

     

    Pyrilutamide vs CB-0301

    Cortexolone 17α-propionate also known as CB-0301 is a topical steroidal anti-androgen. While it has a slightly different structure to NSAAs like pyrilutamide and RU588, it works similarly, blocking testosterone and DHT from binding to the androgen receptor. A Phase II trial of 404 patients was completed in 2019 using male patients aged 18−55 with mild to moderate androgenetic alopecia.

    While the full study results are unpublished, the manufacturers reported that CB-0301 exhibited a good safety profile even after 12 months of treatment. A phase III study using a 7.5% dose is expected to start in the second half of 2022.

     

     Pyrilutamide vs GT20029 

    GT20029 was developed using Kintor's proprietary Proteolysis Targeting Chimera (PROTAC) platform. It works by degrading androgen receptors. It is in the very early phase (phase I) study for the treatment of hair loss acne in China.  It is the first topical androgen receptor (AR) compound (AR-PROTAC) to enter the clinical stage. Kintor's preclinical study has shown that the efficacy of GT20029 is superior to other small molecule AR inhibitors. Results indicated that GT20029 did not cause excessive drug accumulation and notable side effects. Compared with the current oral antiandrogen therapies, topical GT20029 is promising to be a new clinical option for androgenetic alopecia and acne vulgaris patients to have quick effect and less side effects.

     

    Pyrilutamide - What can we conclude?

    Pyrilutamide is very new and looks like a promising new addition to the hair loss armoury. It has a mechanism of action on DHT function that could see it work similarly to Finasteride and Dutasteride or RU58841 and would likely have similar side effects to these products.

    Unfortunately, it’s hard to say much more than that for the moment. The lack of available information on side effects and safety makes it hard to safely recommend.

    Assuming that the leaked information is genuine, the data suggest that 0.5% pyrilutamide used twice daily is an effective product for male pattern hair loss.

    But…

    Until the study data is published, many questions remain unanswered. Information such as the study design, how the participants were recruited and whether they were taking other hair loss treatments at the same time will affect how reliable these results are.

    The ongoing trials in the US and China will also give a better indication of how promising a treatment this is and it will be very encouraging if their results agree with the data we have so far. Until then, we recommend using Finasteride, Minoxidil and RU58841, which have more information about their safety and effectiveness available.

     

PRODUCT REVIEW

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Reviews

Verified Buyer
5
04/24/23
This works
Finasteride didn’t work. dutasteride didn’t work. Minoxidil did absolutely nothing. But this right here, Pyrilutamide actually reversed and regrew hair!
Verified Buyer
4
09/21/22
Price going down?
Is the price going to go down anytime soon?

Reply From Seller: The price is expected to go down in the future when there are more manufacturers making this material. Currently there is only one lab in the world that makes this compound in a very limited quantity.
Verified Buyer
5
10/26/22
love the product
I am buying this product the 2nd time today. Love the product.
Verified Buyer
5
01/22/23
Cream version?
Was wondering if their will be a cream version of Pyrilutamide this like your S5 spironolactone cream? I still have good bunch of hair and find using a small amount of cream twice a day to be far less messy that using an Liquid solution.
Verified Buyer
4
03/15/23
Pyri
It's only been 3 months so I don't think it's been enough time to warrant photos. I do see less hair falling out when I shower.
Verified Buyer
5
09/14/22
Version with Minoxidil
Version with Minoxidil 5% would be great! Same as Ru product.

Reply From Seller: : Technically we can make a minoxidil with pyriluatmide solution. However, the stability is a concern as water is present in minoxidil solution, which makes it unstable
On another note, PyriPure dries pretty fast. So it is easy to apply PyriPure first and then apply a minoxidil solution.
Verified Buyer
3
10/09/22
Pyrilutamide purity test
Do you test every batch for purity? Or did you just test it once?

Reply From Seller: We test every batch of new raw material.
Verified Buyer
5
01/20/23
Got my product, and will try to stop my diffuse thinning
Got my product(Pyri), and will try to stop my diffuse thinning
Verified Buyer
5
02/10/23
Nice product
Until now it's a nice product. I ordered one botlle to test if I can tolerate. Until now I use it a week without any sides. I only have some itching on my scalp after applying it. But after 30 minutes it's gone. I don't have this with other products from minoxidilmax, but I'm okay with it. And it dries really fast. I already use minoxidil and essengen-f with good results, so I thought I give pyrilutamide a try as extra boost that blocks the dht to bind to the hair follicle, and the topical finasteride to reduce the scalp dht. We will see in a few months if it helps, but I have good hope it helps.
Verified Buyer
5
09/12/22
No PG version
Do you plan on releasing a No PG version too? And if so, when more or less (1 month, 3+ months, 1+ year). Thanks

Reply From Seller: The PG in PyriPure is very minimal. There is a good chance you will be okay with it if you are not super sensitive to PG.

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