Duderma
Price
$50.00
Option
KEY INGREDIENT
  • Dutasteride:  0.1% (1 mg in each ml).

     

TWO VERSIONS
  • We offer DuDerma in two versions. One is formulated with proplylene glycol (PG), the other is without PG (PG Free).

    Both versions can be selected from the product Options (next to the product price). 

    If you are not sure whether you are allergic to PG, you can choose the regular DuDerma (~15% people are allergic to PG with symptoms such as itching scalp and skin rashes).

    If you are allergic to PG, Duderma PG Free is the best topical dutasteride solution without minxidil for you. 

    Duderma is a dutasteride only product. We have other topical dutasteride products enhanced with minoxidil and/or finasteride (See details below). 

MORE INFO
  • Unit size: 60 ml (2oz). If you choose 60ml x 3, you will receive 3 units, each with 60 ml. 

    Concentration: 0.1% (1mg in each ml)

    Each unit comes with a dropper.

    If the concentration is too high for your usage, you can dilute DuDerma with the PG Solvent, or DuDerma PG Free with PG Free Solvent. If you mix one unit of Duderma with one unit of the Solvent, you will get 120 ml (4 oz) of 0.05% topical solution. To make a 0.025% topical dutasteride solution, you will add 20 ml of DuDerma to 60 ml of PG Solvent/PG Free Solvent.

     

ABOUT DUTASTERIDE
  • It is usually abbreviated as Dut in hair loss community. It is a type I and type II 5α-reductase inhibitor (Finasteride is a type II 5α-reductase inhibitor only) . 5α-reductase is an enzyme that converts testosterone to dihydrotestosterone (DHT). Excessive amount of DHT in the scalp is believed to be responsible for hair loss. The figure below shows how different products work for hair loss treatment. As shown, both finasteride and dutasteride work by inhibiting 5-alpha reductase, while other products such as RU58841,spironolactone, and ketoconazole work by preventing DHT from binding to hair follicles. 

    how does topical dutasteride work

     

    Literature:

    "A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dut-asteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia" Walter Gubelin Harcha et al. J Am Acad Dermatol. 2014 Mar. Link: https://pubmed.ncbi.nlm.nih.gov/24411083/

    Superiority of dut over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study Sujit J S Shanshanwal et al. Indian J Dermatol Venereol Leprol. Jan-Feb 2017. Link: https://pubmed.ncbi.nlm.nih.gov/27549867/

    Efficacy of  Oral and Duta-steride in the Treatment of Androgenetic Alopecia: A Systematic Review Maira Elizabeth Herz-Ruelas et al. Skin Appendage Disord. 2020 Nov. Link: https://pubmed.ncbi.nlm.nih.gov/33313048/

    "5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety" Rachita Dhurat et al. Dermatol Ther. 2020 May. Link: https://pubmed.ncbi.nlm.nih.gov/32279398/

     

     

Can Dutasteride be Absorbed through Skin?
  • You may know the 500 Dalton rule, which says any molecule with a molecular weight (MW) over 500 Dalton is difficult to be absorbed through skin.

    Dut is 528.5 Dalton. Thus some people question if topical dutasteride is effective. An article discussing the 500 Dalton rule can be viewed here .

    In the article, it has the figure below. It shows the penetration rate of a molecule through a normal skin (NS) decreases rapidly when the molecular weight (MW) is over 500 Dalton. However, the rate does not become zero until MW reaches 600 Dalton. The penetration rate of dutasteride (mw: 528.5Dalton) is estimated to be still >50% if the figure is accurate. This means it can be absorbed through skin, althought it may not be as fully as smaller molecules. 

    In addition, we have no doubt that Duderma can penetrate skin based on the feedback of our customers (see the product review at the end of this page).

     

     

PRODUCT IMAGE
  • duderma

FREQUENTLY ASKED QUESTIONS
  •  

    Can I mix Duderma with other topical solution solutions you have and use it together?

    This product is miscible with any other topical minoxidil/finasteride solutions we offer and you can mix them in any ratios. 

    For your convenience, we also offer a product containing Dut with minoxidil (brand name MinoDuta), and a product containing Dutasteride, finasteride, and minoxidil (brand name FinoDuta). 

     

    How stable is this product? 

    Topical dutasteride solution is pretty stable. All of our products are freshly made. It is stable for at least one year after you receive the product.

     

    How should I use this product? 

    All ingredients used in this product are medical grade. The product is for laboratory research only. You will decide how to use the product.  

     

    What is the difference between dutasteride and finasteride? 

    The structure of Dut and finasteride (Fin) are shown below. Both have similar structure to that of testosterone, the substrate of 5-alpha-reductase (5AR).  That is the exact reason why they can bind to the active site of 5AR and inhibit its activity. Both Dut and Fin are very good 5AR inhibitors (or DHT blocker). They tackle hair loss by inhibiting 5AR activity to reduce DHT level. 

    The difference between dut and fin are: (1) Dut is a stronger DHT blocker. Dut is a both type I and type II 5AR inhibitor, while Fin is a type II 5AR inhibitor only.  For type II 5AR, duta-steride is approximately three times more potent than finasteride.

    Dut has a much longer half life than fin in the human body (4-5 weeks vs 5-6 hours).

PRODUCT REVIEW

27 Reviews
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Reviews (27)

Verified Buyer
5
06/10/21
Great Results
I'm male and have a a receding front hairline, which got much more noticeable recently due to stress. I started using DuDerma about 10 weeks ago and my hairline has improved immensely. I use the product twice daily. Love the resists. I'm amazed and very satisfied.
Verified Buyer
5
08/24/21
Very good product
As DuDerma is more potent at lowering DHT compared to Finasteride I’ve been using a super low dose of DuDerma which equates to 0.1mg daily. I mix it with 2ml of NO PG solvent to help with scalp coverage as I’m a diffused thinner. So far so good and as you may notice from the before picture and now current picture there is definitely a improvement. I will start to incorporate Dulagen-5R to my routine once it arrives to see if this helps with anymore regrowth and will do a update once I’ve had some time with it. Hope MinoxidilMax can bring a 5% RU product out too as believe that this would cover all bases in scalp androgens and maximize hair growth.
Verified Buyer
5
03/16/21
Great Product
Great product, would love to see this in combination with minoxidil and other products.

Reply From Seller : Thank you for your suggestion. Now we offer MinoDuta (minoxidil with dutasteride) and FinoDuta (minoxidil with finasteride and duasteride).
Verified Buyer
5
02/10/22
promised item
I am using this 3 times a week ,each 1ml with minoxidil 10% about 2 months. I can keep less hairfall ,and thick hair It's not sticky and easy to use .
Verified Buyer
5
06/06/21
PG
Just wanted to add - although PG is a bit of a nuisance- it is one of the most effective vectors for taking other molecules through the skin and that includes the scalp - I noticed the comments regarding PG free solutions - some people have a slight allergic reaction to it but if you don't, use it, because as a carrier it will work much more effectively than any other substrate you used to get products through the skin epidermis
Verified Buyer
4
03/12/21
Please offer a topical dutasteride solution without PG.
This is a good stuff but the PG is killing me.

Would love a version without PG Many hair loss sufferers are allergic to propylene glycol, unfortunately so am I. I would love a version of this without PG. Reply from Seller: Thank you for your suggestion. Now it is available.
Verified Buyer
3
11/04/21
Dutasteride
I have used it for almost 4 weeks. Since I started my scalp itching has been away. Unfortunately the hair loss is still falling, and I am afraid dutasteride is not getting through the skin. I have tried to use dermaroller 1.5 mm before the topic solution, but I have not obtained the desired effect. I will give it 2 more months before I have my final conclusion.
Verified Buyer
5
06/06/21
Game changer
I have been using this for a few months now and have noticed some major improvements in hair regrowth - I have been using it in conjunction with 15% minoxidil max solution- - I use the 15% minoxidil in the morning and the Duderma around 6.00pm - then 15% minoxidil at night- Unlike finasteride - the DuDerma blocks both of the reductase (1 and 2) enzymes that convert Testosterone to DHT which weakens and destroys the hair follicles- I honestly think the DuDerma could be a game changer regarding hair loss in men
Verified Buyer
3
03/12/21
Would love a version without PG
Many hair loss sufferers are allergic to propylene glycol, unfortunately so am I. I would love a version of this without PG.

Reply from Seller Thank you for your suggestion. We do have a version without PG now.
Verified Buyer
5
10/03/21
First product which has ever worked on me
This is the first product which has ever worked on me. I have used minoxidil and finasteride with no regrowth. I have only used this less than a month and I could definitely see new hair growth. Thank you minoxidilmax for making this product.

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