Dutasteride: 0.1% (1 mg in each ml).
We offer DuDerma in two versions. One is formulated with proplylene glycol (PG), the other is without PG (PG Free).
Both versions can be selected from the product Options (next to the product price).
If you are not sure whether you are allergic to PG, you can choose the regular DuDerma (with PG). Approximately 15% people are allergic to PG with symptoms such as itching scalp and skin rashes.
This topical dutasteride product is without any minoxidil or finasteride. It is a dutasteride only product.
Unit size: 60 ml (2oz). If you choose 60ml x 3, you will receive 3 units, each with 60 ml.
Concentration: 0.1% (1mg in each ml)
Each unit comes with a dropper.
If the concentration is too high for your purpose, you can dilute DuDerma with the PG Solvent, or DuDerma PG Free with PG Free Solvent. If you mix one unit of Duderma with one unit of the Solvent, you will get 120 ml (4 oz) of 0.05% dutasteride solution.
Dutasteride is a type I and type II 5α-reductase inhibitor (Finasteride is a type II 5α-reductase inhibitor only) . 5α-reductase is an enzyme that converts testosterone to dihydrotestosterone (DHT). Excessive amount of DHT in scalp is believed to be responsible for hair loss.
"A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia" Walter Gubelin Harcha et al. J Am Acad Dermatol. 2014 Mar. Link: https://pubmed.ncbi.nlm.nih.gov/24411083/
Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study Sujit J S Shanshanwal et al. Indian J Dermatol Venereol Leprol. Jan-Feb 2017. Link: https://pubmed.ncbi.nlm.nih.gov/27549867/
Efficacy of Oral and Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review Maira Elizabeth Herz-Ruelas et al. Skin Appendage Disord. 2020 Nov. Link: https://pubmed.ncbi.nlm.nih.gov/33313048/
"5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety" Rachita Dhurat et al. Dermatol Ther. 2020 May. Link: https://pubmed.ncbi.nlm.nih.gov/32279398/
You may know the 500 Dalton rule, which says any molecule with a molecular weight (MW) over 500 Dalton is difficult to be absorbed through skin.
Dutasteride is 528.5 Dalton. Thus some people question if topical dutasteride is effective. An article discussing the 500 Dalton rule can be viewed here .
In the article, it has the figure below. It shows the penetration rate of a molecule through a normal skin (NS) decreases rapidly when the molecular weight (MW) is over 500 Dalton. However, the rate does not become zero until MW reaches 600 Dalton. The penetration rate of dutasteride (mw: 528.5Dalton) is estimated to be still >50% if the figure is accurate. This means dutasteride can be absorbed through skin, althought it may not be as fully as smaller molecules.
In addition, we have no doubt that dutasteride can penetrate skin based on the feedback of our customers (see the product review at the end of this page).
Please be advised that any dutasteride containing product is for research only. It is not intended for the diagnosis, treatment, cure, or prevention of any disease or condition. Please familiarize yourself with the product and use it at your own risk.