Duderma
Price
$50.00
Option
KEY INGREDIENT
  • Dutasteride:  0.1% (1 mg in each ml).

     

TWO VERSIONS
  • We offer DuDerma in two versions. One is formulated with proplylene glycol (PG), the other is without PG (PG Free).

    Both versions can be selected from the product Options (next to the product price). 

    If you are not sure whether you are allergic to PG, you can choose the regular DuDerma (with PG). ~15% people are allergic to PG with symptoms such as itching scalp and skin rashes. 

    This product is without any minoxidil or finasteride. It is a dutasteride only product. We have other products that have them together. 

MORE INFO
  • Unit size: 60 ml (2oz). If you choose 60ml x 3, you will receive 3 units, each with 60 ml. 

    Concentration: 0.1% (1mg in each ml)

    Each unit comes with a dropper.

    If the concentration is too high for your usage, you can dilute DuDerma with the PG Solvent, or DuDerma PG Free with PG Free Solvent. If you mix one unit of Duderma with one unit of the Solvent, you will get 120 ml (4 oz) of 0.05% topical solution. To make a 0.025% topical dutasteride solution, you will add 20 ml of DuDerma to 60 ml of PG Solvent/PG Free Solvent.

     

ABOUT DUTASTERIDE
  • It is usually abbreviated as Dut in hair loss community. It is a type I and type II 5α-reductase inhibitor (Finasteride is a type II 5α-reductase inhibitor only) . 5α-reductase is an enzyme that converts testosterone to dihydrotestosterone (DHT). Excessive amount of DHT in the scalp is believed to be responsible for hair loss. The figure below shows how different products work for hair loss treatment. As shown, both finasteride and dutasteride work by inhibiting 5-alpha reductase, while other products such as RU58841,spironolactone, and ketoconazole work by preventing DHT from binding to hair follicles. 

    how does topical dutasteride work

     

    Literature:

    "A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dut-asteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia" Walter Gubelin Harcha et al. J Am Acad Dermatol. 2014 Mar. Link: https://pubmed.ncbi.nlm.nih.gov/24411083/

    Superiority of dut over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study Sujit J S Shanshanwal et al. Indian J Dermatol Venereol Leprol. Jan-Feb 2017. Link: https://pubmed.ncbi.nlm.nih.gov/27549867/

    Efficacy of  Oral and Duta-steride in the Treatment of Androgenetic Alopecia: A Systematic Review Maira Elizabeth Herz-Ruelas et al. Skin Appendage Disord. 2020 Nov. Link: https://pubmed.ncbi.nlm.nih.gov/33313048/

    "5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety" Rachita Dhurat et al. Dermatol Ther. 2020 May. Link: https://pubmed.ncbi.nlm.nih.gov/32279398/

     

     

Can Dutasteride be Absorbed through Skin?
  • You may know the 500 Dalton rule, which says any molecule with a molecular weight (MW) over 500 Dalton is difficult to be absorbed through skin.

    Dut is 528.5 Dalton. Thus some people question if topical dutasteride is effective. An article discussing the 500 Dalton rule can be viewed here .

    In the article, it has the figure below. It shows the penetration rate of a molecule through a normal skin (NS) decreases rapidly when the molecular weight (MW) is over 500 Dalton. However, the rate does not become zero until MW reaches 600 Dalton. The penetration rate of dutasteride (mw: 528.5Dalton) is estimated to be still >50% if the figure is accurate. This means it can be absorbed through skin, althought it may not be as fully as smaller molecules. 

    In addition, we have no doubt that Duderma can penetrate skin based on the feedback of our customers (see the product review at the end of this page).

     

     

PRODUCT IMAGE
  • topical dutasteride

FREQUENTLY ASKED QUESTIONS
  •  

    Can I mix Duderma with other topical solution solutions you have and use it together?

    This product is miscible with any other topical minoxidil/finasteride solutions we offer and you can mix them in any ratios. 

    For your convenience, we also offer a product containing Dut with minoxidil (brand name MinoDuta), and a product containing Dutasteride, finasteride, and minoxidil (brand name FinoDuta). 

     

    How stable is this product? 

    Topical dutasteride solution is pretty stable. All of our products are freshly made. It is stable for at least one year after you receive the product.

     

    How should I use this product? 

    All ingredients used in this product are medical grade. The product is for laboratory research only. You will decide how to use the product.  

     

    What is the difference between dutasteride and finasteride? 

    The structure of Dut and finasteride (Fin) are shown below. Both have similar structure to that of testosterone, the substrate of 5-alpha-reductase (5AR).  That is the exact reason why they can bind to the active site of 5AR and inhibit its activity. Both Dut and Fin are very good 5AR inhibitors (or DHT blocker). They tackle hair loss by inhibiting 5AR activity to reduce DHT level. 

    The difference between dut and fin are: (1) Dut is a stronger DHT blocker. Dut is a both type I and type II 5AR inhibitor, while Fin is a type II 5AR inhibitor only.  For type II 5AR, duta-steride is approximately three times more potent than finasteride.

    Dut has a much longer half life than fin in the human body (4-5 weeks vs 5-6 hours).

PRODUCT REVIEW

24 Reviews
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Reviews (24)

Verified Buyer
5
06/04/21
Reversed balding
I had a clear bald patch on the crown and receding at the front. I have used this for months and whilst it has not 100% covered up nor is it hair transplant thick I am no longer bald. I'd say my hair has gone back about fifteen years in time. Which at my age is about as good as you can expect. With Fint/Dutasteride it is best to think they will stop you going more bald rather than getting insane growth. Yes you can be lucky. And the earlier you tackle your hair loss the better.
Verified Buyer
5
06/20/21
Seems to work
As I was young and did not want to be bald, I had a hair transplant. At the beginning, everything worked out well. I used minoxidil regularly, but it had a little effect on hair loss. I found topical dutasteride when I was almost desperate about my progressive balding. So far, it seems to work, at least the progression of hair loss seems to have stopped. Good thing is that I have not noticed any side effects (for example, with finasteride pills had loss of libido). I am looking foward to long term results, as I have used it only for a couple of mounths.
Verified Buyer
5
03/10/21
Great seller and product
I used Essengen-6 Plus for a few years. The result is good but seems plateaued. I want to give dutasteride a try to boost my regrowth. I asked MinoxidilMax if they could offer topical solution. They were kind enough to make it and let me try it. I used this product for one week. It is too early to see any difference. The solution is odorless. It dries very quickly. I mixed it with Minoxidilmax PG Solvent to bring it to 0.1%. I used only 0.5 ml of the diluted solution. So it is about 0.5 mg a day.
Verified Buyer
5
03/24/22
Completely regrew my hairline
I have been using minoxidil and finasteride for +20 years and have kept my hair. However I sometimes experience periods of increased hair loss in the front. I wrote to Leslie from Minoxidil Max and she recommended DuDerma. Have been using it for app 4 months now and my hairline is perfect. This is truly the mixing link and a miracle product in hair regrowth.
Verified Buyer
5
06/11/21
Great product
I have used Dualgen-15 Plus for a several year. The result seems plateaued. Using Duderma every other day definitely helped. My hair is healthier and fuller than before after 3 months. By the way, the solution is very easy to use. It dries instantly.
Verified Buyer
5
03/21/21
dupa hair loss
i have dupa hair loss, i tried everything you can think of ZIX, topical finasteride, finasteride, RU58841, flutamide, bicalutamide, cetirizine.... and many more over a period of 4 years, nothing was working even a little bit. This is the only product that significantly reduced my hair loss all over my head. i apply just 1.5 ml twice a week since 6 month, 1.5ml on sunday on the top / 1,5 ml on wednesday on the side and back and repeat.
Verified Buyer
5
02/10/22
promised item
I am using this 3 times a week ,each 1ml with minoxidil 10% about 2 months. I can keep less hairfall ,and thick hair It's not sticky and easy to use .
Verified Buyer
5
08/11/21
Duderma is a great product. It is more than I expected
Excellent product. It is effective and I avoid using the oral product. Great quality
Verified Buyer
3
11/04/21
Dutasteride
I have used it for almost 4 weeks. Since I started my scalp itching has been away. Unfortunately the hair loss is still falling, and I am afraid dutasteride is not getting through the skin. I have tried to use dermaroller 1.5 mm before the topic solution, but I have not obtained the desired effect. I will give it 2 more months before I have my final conclusion.
Verified Buyer
5
06/28/22
Good results
I use or since a few month and have Seen thé results rapidly. I recommand it

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