What is RU58841?
It is also known as RU, PSK-3841 or HMR-3841, and is a nonsteroidal anti-androgen (NSAA). Its structure is shown below. It is nonsteroidal because it does not have the steroidal skeleton structure. It was investigated and developed by ProStrakan (a Scottish based specialty pharmaceutical company) for its potential therapeutic applications in conditions that were driven by androgens. Conditions, such as acne, hirsutism (excessive hair growth), and androgenetic alopecia (male-pattern hair loss). ProStrakan conducted two clinical studies, phase I and II, and the results of 5% RU-58841, when applied twice daily, were reported to be similar to finasteride.
How does it work?
As a non-steroidal anti-androgen, RU binds itself to androgen receptors and directly inhibits the effects of endogenous (from our own body) androgens such as testosterone and dihydrotestosterone (DHT). As a first generation non-steroidal anti-androgen, it selectively competes for the androgen receptors. This competition effectively attenuates the activity of testosterone and DHT, leading to an overall anti-androgen effect.
The way it works is similar to that of spironolactone, and ketoconazole, a key ingredient used in hair loss shampoo.
It differs from finasteride or dutasteride, which inhibits the activity of 5α-Reductase, an enzyme that converts testosterone into dihydrotestosterone (DHT). DHT is the primary hormone that causes hair loss in men. See the figure below.
Based on the mechanism, it is apparent that finasteride and dutasteride may lead to a decreased DHT level, while RU58841 does not. DHT is pivotal to a male's sexual functionality, that is reason why some people choose RU instead of finasteride. This is also why more people are using topical finasteride instead of oral form to avoid its systemic effect (lowering DHT on the scalp instead of the whole body).
Topical RU solution has a relatively short half-life (1 hour) in comparison to Finasteride (6 hrs) and minoxidil (4 hrs).
How do you control the quality of the product?
Each batch is tested by a 3rd party. Only material that is tested to be >99% pure will be used in our product. (See the test report for the most recent batch).
How long does one unit last?
The product is for research use only. Only the user knows how long one bottle will last. One unit is 60 ml (not 30 ml) of 5% RU58841 (i.e. 50 mg/ml). There is 3 grams of RU in one unit.
Can I mix RuDerma with a minoxidil solution?
RuDerma can be mixed with any of our minoxidil products. They are miscible to each other and the mixture is stable for at least 2 months. This product can be mixed with other liquid minoxidil of different brands, such as Kirkland.
Why can't you make a product with both minoxidil and RU?
Such a product is not difficult to compound. However, the shelf-life is a concern. Minoxidil solution contains water, which RU would like to avoid if a long shelf-life is needed.
How to use RuDerma?
The product is for research purposes only. You will decide how you will use the product. We buy our materials from reliable sources and confirm the purity and identity after we receive them. Ru58841 used in RuDerma is >99% pure.
What is the solvent composition?
We can't disclose the exact composition of the solvent because it is our trade secret. However, we can say that the regular RuDerma has propylene glycol and ethanol (aka, alcohol) and RuDerma PG Free has glycerin and ethanol.
How stable is RU58841?
There is conflicting information about the stability of the RU premixed solution. Some say it is stable for years even when it is stored at room temperature, while others say it is only stable for up to 2 weeks. The truth probably lies somewhere in between.
If the solution was stable for only two weeks, it is unlikely that ProStrakan would even conduct the phase I and II clinical trials. The project must have been killed long before that.
Also RU does not seem unstable based on its molecular structure (see above). The nitrile group (-C≡N) is the lest stable part of the molecule. It can be hydrolyzed in a basic or acid solution (in the presence of water). It is worth noting is that RuDerma is formulated without water. It is freshly made and good for at least one year after the product is shipped.
Stability of RU58841 powder:RU powder is stable for at least two years when stored in an airtight container in a freezer.
RU58841 Side Effects
Unfortunately, there are no phase III clinical trials for this material. Hence, there is no publicly available longitudinal data concerning its side-effect and safety profile in humans. Indeed, the last known study to have verified its efficacy and performance was published in 2005 [Munster, U., et al., RU5-8841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia. Pharmazie, 2005. 60(1): p. 8-12.]. No studies in the literature have been scoped to identify any risks and side-effects of this product. However, the side-effects can be extrapolated based on its classification as a non-steroidal anti-androgenic compound.
Simply speaking, RU doesn't decrease DHT levels. However, it hinders the function of DHT. Thus, it may cause similar sexual side effects caused by the difficiency of DHT.
It is worth noting that someone who gets side effects from finasteride or dutasteride may not necessarily get side effects from RU, and the opposite is true.
RU58841 vs finasteride
As mentioned above, RU58841 and finasteride all work by disrupting the DHT pathway. Fin decreases the production of DHT, while RU prevents DHT from binding to androgen receptors. Both substances may lead to similar side effects because they all affect the function of DHT. Some people think topical RU may have an advantage over fin because it is more of local effect, having less systemic sides than 5a-redutase inhibitors such as fin.
Most people prefer use fin because its safety profile is well established by many clinical trials on human subjects and it is FDA approved to treat hair loss. At the same time, RU never had a phase III clinical study. In addition, fin is well tolerated by most people. The chance of having fin side effects is low. If topical finasteride is used, the possibility of having side effects is even lower. Nonetheless, if someone is super sensitive to fin or dut and absolutely can't tolerate them in any form, is RU an option then?
RU58841 vs minoxidil
Minoxidil is the no.1 hair loss treatment. It is FDA approved to treat hair loss for since 1988. It is an antihypertensive vasodilator.
The mechanism by which minoxidil promotes hair growth is not fully understood. In theory, it widens blood vessels and opens potassium channels, allowing more oxygen, blood, and nutrients to the follicles. In addition, minoxidil contains a nitric oxide moiety and may act as a nitric oxide agonist. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase.
One thing for sure is that minoxidil does not affect DHT level or its function. Therefore, it won't cause any sexual side effects.
Do you ship to my country?
We ship worldwide, including all European countries. We will cover the VAT and duty taxes when we ship to European and any other countries.
What happens if my package gets lost?
We will reship your order if your package gets lost during the shipping. More shipping related questions can be found here.