How Does Topical Spironolactone Work?
Oral spironolactone has been used as a potassium-sparing diuretic since 1960s, marketed under a variety of
Does Topical Finasteride Work?
Topical finasteride is usually compounded with minoxidil. According to the experiences of several hair loss clinics, a topical solution with both finasteride and minoxidil offers similar or even better results than taking minoxidil together with an oral finasteride pill (1mg).
Azelaic acid is a naturally occurring substance that studies have shown to inhibit 5-alpha-reductase in human skin. 5-alpha-reductase converts testosterone into dihydrotestostrone (DHT), accumulation of which in scalp is believed to be responsible for the male pattern hair loss. Inhibition of this enzyme by azelaic acid can reduce the concentration of DHT in scalp and therefore stimulate hair regrowth. Azelaic acid can be found in many prescription acne medications. Azelaic acid is added to minoxidil solutions because it has different mechanism of action in preventing hair loss. Finasteride is a synthetic chemical; it is one of two
Jun/17
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1. What is 15% minoxidil?
Answer: It is the most potent minoxidil solution available. In the 15% minoxidil solution, 15% of the weight of the solution is minoxidil. In another words, if you have one millilitre of the solution and dry it out, you should get roughly 150 milligrams of minoxidil. In comparison, if you do the same with 1 millilitre 5% Kirkland minoxidil, you will get roughly 50 milligram minoxidil.
If you don't know what minoxidil is, minoxidil is the number 1 hair regrowth product in the US and around the world. It is FDA approved for hair regrowth. It has been
Why is Minoxidil Sulfate a Bad Idea?
Very often I receive questions asking why I do not recommend minoxidil sulfate in a hair regrowth product. Perhaps they've read somewhere minoxidil sulfate works better than minoxidil.
Here I explain why I do not recommend minoxidil sulfate. The structure of real minoxidil sulfate is shown in the Figure below. It is the active metabolite that stimulates hair follicles. Minoxidil applied to the scalp is automatically converted into minoxidil sulfate by sulfotransferase in the scalp (see article 1 below). Yeah, you got it. First of all, it is not necessary because minoxidil will be converted to minoxidil sulfate by the enzymes in your body. Not only is it unnecessary to
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