Minoxidil: Minoxidil is the only FDA approved and most widely used ingredient for hair regrowth as of today. It was first used as an oral drug to lower blood pressure. It was soon found to stimulate hair growth in those who took it to lower blood pressure. Rigorous clinical studies have confirmed this “side effect” and its FAD approvals for hair regrowth as topical solutions were granted, which are summarized in the table below. 

FDA approvals of Minoxidil solution

1979—Oral formulation approved by the FDA for severe hypertension

1988—FDA approval for the 2% solution, with prescription, for hair loss in men with AGA

1992—FDA approval for the 2% solution for hair loss in women

1996—FDA approval for the 2% solution for OTC use in men and women with AGA

1997—FDA approval for the 5% solution for OTC use in men, labeled as “extra strength for men”

2006—FDA approval for the 5% foam (Rogaine®) for OTC use in men

AGA, Androgenetic alopecia; FDA, US Food and Drug Administration; OTC, over the counter.

The effectiveness of minoxidil solution on hair growth is dosage dependent, which is evident by the history of minoxidil products approved by FDA. Although minoxidil is the first and only topical solution approved by FDA as of today, the mechanism by which minoxidil promotes hair growth is not fully understood. Several mechanisms have been proposed. None of them involves blocking 5-alpha-reductase activity (DHT blocker) as azelaic acid does.

Even though minoxidil is the only ingredient approved by FDA for hair regrowth, it does not mean there are no other effective ingredients that would cope with hair loss. Worth noting is that it takes years and costs hundreds of millions dollars to go through the rigorous clinical studies required by FDA to obtain its approval.  Therefore, it is not surprising that there are good stuff out there that are clinically proven to be effective but not approved by FDA yet due to the prohibitive cost of FAD approval process. Below are several clinically proven ingredients that are used in some of our products.

Azelaic Acid: Azelaic acid is a naturally occurring substance found in whole grains that studies have shown to inhibit 5-alpha-reductase in human skin. 5-alpha-reductase converts testosterone into dihydrotestostrone (DHT), accumulation of which in scalp is believed to be responsible for the male pattern hair loss. Inhibition of this enzyme by azelaic acid can reduce the concentration of DHT in scalp and  therefore facilitate hair regrowth.  Azelaic acid can be found in many prescription acne medications. Azelaic acid is added to minoxidil solutions because it has different mechanism of action in preventing hair loss. The combination of them results in a more efficient and effective method to decrease the levels of DHT and speed up the process of hair regrowth significantly.

Possible side effects of azelaic acid include: a) increased sensitivity or irritation on the scalp; 2) burning, stinging, or tingling of the skin; 3) erythema, dryness, rash, peeling happens in less than 1% of patients. The side effects usually subside after discontinuing use of azelaic acid

Retinol: studies showed that combining minoxidil and retinol works better than minoxidil alone due to the enhanced penetration of minoxidil and improved scalp condition [ Yoo HG et al, "the additive effects of minoxidil and retinol on human hair growth in vitro." Bio Pharm Bull. 2007, 20(1): 21-6].

Caffeine: Studies published in peer-reviewed scientific journals have shown that not only caffeine reverses the suppressive effects of Testosterone on the growth of follicle but also is a very strong stimulator of the hair follicle growth [Fisher TW et al, "Effect of Caffeine and Testosterone on the proliferation of human hair follicles in vitro" International Journal of Dematology, 6(1): 27-35].

Procyanidin Oligomers: naturally derived ingredients that have shown to stimulate hair growth similarly to Minoxidil. Research studies have shown that procyanidin oligomers possess growth stimulation activity toward hair epithelial cells in vitro and stimulate anagen induction in hair follicles in vivo. Addition of procyanidin oligomers to LipoGaine is intended to achieve better hair growth stimulation than minoxidil alone.

Saw Palmetto Extract: liposerolic extract of the fruit of saw palmetto. Saw palmetto has shown to effectively block DHT

GLA, ALA,  Linoleic Acid and Oleic Acid: Gamma Linolenic Acid (GLA), Alpha Linolenic Acid (ALA),  linoleic and oleic acid are essential fatty acids found in plant oils, which have been individually proven to inhibit 5-Alpha Reductase. In fact these are the most powerful inhibitors of 5-Alpha Reductase known today and not only they inhibit the Type II form of the 5-alpha reductase which other products like Propecia® inhibit, but also the Type I form of the enzyme which is present in high concentrations in the scalp, sebaceous glands, and the skin. Additionally GLA, ALA and oleic acid have potent anti-inflammatory properties.

By combining azelaic acid, saw palmetto, GLA, ALA, linoleic acid in LipoGaine, we have created a natural yet extremely powerful anti-DHT formula. These ingredients work through different mechanisms to synergistically inhibit both type 1 and 2 forms of 5-alpha reductase and decrease DHT locally. By decreasing the DHT levels, hair follicles can grow and thicken naturally, leading to a fuller, healthier scalp without the side effects associated with synthetic drugs..

Adenosine, vitamin B6, vitamin B12: Each of these ingredients is required for cell growth, proliferation, and division. Insufficiency of any of them would disturb many enzymatic reactions that are taking place in our body in every second, and can lead to hair loss. Addition of adenosine, vitamin B6 and B12 to ensure sufficient nutrients are provided for your hair regrowth.

Minoxidil sulfateWe do not use minoxidil sulfate in our product. Click here to find out why.