Topical Spironolactone 5% For hair loss and acne
  • Maxogen-S topical spironolactone has the main effective ingredient spironolactone at 5%, a safe antiandrogen that can be used for both men and women. Maxogen-S is absorbed and metabolized rapidly. It only has local effect without any systemic effect. It can be used by both men and women.  Maxogen-S has additional ingredients  Retinol, Caffeine, and Copper tripeptide to enhance its effectiveness. 


    How to use Maxogen-S for hair loss?

    Maxogen-S is very simple to apply. Dab some on your fingertip and apply it to the scalp (try not to get it on your hair). You just need a thin film covering your hair loss area. The lotion is absorbed by your scalp very quickly.  You can use Maxogen-S on its own, twice daily. You can also use it with a minoxidil product like Essengen-5 NO PG Fast Dry, in which case it is recommended to use the minoxidil alone in the morning and use both Maxogen-S and the minoxidil product in the evening. In the evening, you can apply maxogen-S first and wait for half an hour before you apply the minoxidil product. Try not to use too much Maxogen-S. See the picture below for how much Maxogen-S you should use. 



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Topical Spironolactone Frequently Asked Questions
  • How Does Topical Spironolactone Work?

    Oral spironolactone has been used as a potassium-sparing diuretic since 1960s, marketed under a variety of brand names, including Aldactone, Novo-Spiroton, Aldactazide, Spiractin, Spirotone, Verospiron and Berlactone. It is often shortened as spiro. It was serendipitously discovered to reduce hair in female who had too much hair (hirsutism) in 1990s. Soon it was used off-label to treat female pattern hair loss by experts in hair loss field. It appears to be counter-intuitive that a substance can be  used to treat both excessive hair and hair loss at the same time. In fact, oral spironolactone works for hirsutism treatment by reducing the testosterone level (female with hirsutism have high male hormone testosterone); while it works as an effective hair loss treatment due to the same reason-- reducing testosterone level. As we know, female and male pattern hair loss is caused by excessive dihydrotestrone (DHT). Testosterone is a precursor for DHT. By reducing testosterone level, it lowers DHT level. In addition, spironolactone binds to DHT receptor of the hair follicles so DHT cannot bind to it and do any damage to the hair.


    Topical Spironolactone results:

    Sinclair et al performed a clinical study with 40 female taking oral spironolactone (200mg daily). It showed 88% of women receiving oral spironolactone either stopped the progression of their hair loss or saw improvement  [Reference 1].

    Carolyn et al did a retrospective study and found that 73% of the subjects (29 out of 39) with female pattern hair loss who received oral treatment (~110mg daily) reported stabilization or improvement of their hair loss  [Reference 2].

    Adamopoulos et al studied the effect of oral spironolactone in 4 young people (age from 19-23 year old) . The four people (two female and two male) took 100 mg spironolactone twice daily for 6 months. Results showed hair loss was reduced significantly and more hairs are in growing phase (anagen phase) in all 4 people. The study also showed a considerable degree of relapse post the treatment, which indicates the continuous use of spironolactone is necessary to keep the result [Reference 3].

    Although there is no official study reported in peer review articles to demonstrate how well topical spironolactone works, there is little doubt it works just as efficient as oral spironolactone. Hair loss experts have used topical spironolactone for hair loss treatment in women and men for long time. Dr. Richard Lee, a Los Angles based dermatologist, was probably the most famous one. He used it to treat his male and female customers for more than 10 years until his retirement.


    Spironolactone vs finasteride

    Spironolactone is a weaker DHT blocker compared to finasteride. Spironolactone can be used by both men and women, while finasteride is for men use only. 

    If you want to have a stronger DHT blocking product, you can consider topical finasteride such as Essengen-6 Plus, or Essengen-F.


    Topical spironolactone side effects? 

    Spironolactone is rapidly and completely metabolized in the skin and does not affect any other organ system. In about 1% of patients, a rash can develop. If this happens, the user should discontinue use of topical spironolactone. .


    What are the drawbacks to the use of topical spironolactone?

    Although topical spironolactone is pharmacologically one of the very effective topical treatments for male and female pattern baldness, there are inherent drawbacks, e.g. spironolactone has a disagreeable odor if it is not formulated right. We spent years of research and development to minimize the unpleasant odor. 


    What would be recommended to use with this product for hair loss treatment?

    If you want to use minoxidil with this product, you can buy any minoxidil product  we offer. If you tolerate minoxidil very well, you can use Maxogen-S along with our Dualgen-15 NO PG


    Maxogen-S topical spironolactone for acne

    Maxogen-S is not only effective in hair loss treatment, but also effective in treating acne. In a retrospective clinical study with 110 patients treated with spironolactone for acne, 94 patients saw improvement and 61 of them completely were completely acne free. The patients saw an average improvement in their acne by 73.1% for the face, 75.9% for the chest, and 77.6% for the back. Spironolactone was also demonstrated to be effective in treating acne in topical formulation according to dermatologist Steven Mandy. When using Maxogen-S for acne treatment, you just need a thin film covering the area you want to treat. Use the product twice daily, one in the morning and the other in the evening. People typically see improvement in 2 to 3 weeks with continous use.  




  • Maxogen-S topical spironolactone ingredients:

    5% spironolactone,  retinol,  caffeine,  copper tripeptide


    Complete Ingredients List:

    Water, glycerin, 5% spironolactone, niacinamide, isopropyl isostearate, dimethicone, panthenol, caprylic/capric triglyceride, tocopheryl acetate, copper tripeptide, palmitoyl pentapeptide-4,  dimethiconol, cetearyl glucoside, cetearyl alcohol, sodium peg-7 olive oil carboxylate, retinol, stearic acid, palmitic acid, caffeine, cetyl alcohol, behenyl alcohol, disodium edta, polyethylene, sodium acrylates copolymer, polyacrylamide, citric acid, fragrance


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Verified Buyer
Works as described without any side effects
This is probably the safest DHT blocker. It is easy to use. I used alone for my frontal hair loss. It worked great to stop my hairline from receding. It also regained some ground, I believe.
Verified Buyer
hormonal acne treatment
I just ordered my third jar. This has almost completely cured the mild but cystic acne on my chest and back and chin. I also had dark, coarse chin hairs, and this cream has retarded their growth, and in time, I think they will not grow anymore. I also had hair thinning on my head, but not bad enough to use this cream on my head (the acne was my first concern). However, this cream has indirectly treated my hair loss too without my even using it on my head. I have had all the classic signs of high androgen levels. My only other treatment, besides, this cream has been 2 cups of loose-leaf organic spearmint tea daily (cold infusion method) and spearmint essential oil used in my bath water. I am beyond grateful to have found this cream. THANK YOU!
Verified Buyer
Spiro Cream
If you have thinning hair, this should be part of your regimen. Spiro is clinically proven to lower androgens. Topically applied reduced DHT on scalp. If you really want to make progress with your hair this is a big part. I could go on, but it’s safe & reasonably priced.
Verified Buyer
Removed scalp itch and reduced hairfall.
Hello. I used this product for 3 months and I can honestly say it reduced scalp itch and reduced hairfall very fast, it doesnt hurt to try it. Spiro cream is a safer alternative to RU, RU actually damaged my hair but this spiro cream did not. A little known fact spiro and RU works the same way by attatching to the hair folicle receptor blocking it so DHT and T cant attatch to it.
Verified Buyer
It works so well. About 2 months after using this product, my hair has changed a lot. Of course, I put in a lot of effort including eating, exercising, sleeping, and nutritional supplements.
Verified Buyer
Maxogen-s, a must use product for hairloss
They say the big 3 but I would change that to big 4,for max hairloss protection, a topical anti-androgen is needed to block testosterone on scalp.
Verified Buyer
All around great quality
On top of being an active topical spironolactone, it is actually a very well thought out formula with very high quality ingredients. I use it for acne and it works wonders! I love that it has caffeine and retinol as well! Would recommend to anyone with hormonal acne or hair loss
Verified Buyer
Topical Spirolactone
This is a hard product to find. Spirolactone reduces androgens which gives scalp better chance to grow healthy hair. Women have 90% less male androgens. Universally their hair is thicker, growing faster etc. It’s a nice white cream & is part of my regimen. You should also use a strong 15% Minoxidil topical. I use a healthy shampoo. Plus essential oils & Vitamin B 12 complex hair treatments. There are other things, but this is an essential.
Verified Buyer
All around great quality
On top of being an active topical spironolactone, it is actually a very well thought out formula with very high quality ingredients. I use it for acne and it works wonders! I love that it has caffeine and retinol as well! Would recommend to anyone with hormonal acne or hair loss
Verified Buyer
Works for hormonal/jawline acne
I've been using the product for hormonal/jawline acne for more than a month and there is a noticeable improvement in my skin.