DualGen-15 NO PG Plus

DualGen-15 NO PG Plus

For Information Only. Product is NOT offered.

FEATURES
  •  The Ultimate Hair Regrowth Solution: DualGen-15 NO PG Plus is the most powerful solution available for fighting against hair loss. Compared to  Dualgen-15 NO PG, this product has additional topical finasteride.

    ✔ Two FDA Approved Ingredients in One Solution: DualGen-15 NO PG Plus has the maximum strength of FDA approved hair growth stimulator (15% minoxidil) and DHT blocker Finasteride (0.1%) with other auxiliary ingredients such as Azelaic acid (5%), Retinol (0.25) and Caffeine.

    ✔ No Need to Take Finasteride Pill: If you are currently taking 1mg finasteride pill a day, you don't need to continue to take the pill if you use this topical solution. The amount of finasteride in each mL is 1 mg.

    ✔ Who Should Use DualGen-15 NO PG Plus:  This product is intended for men with advanced hair loss. It is most suitable for those who used Dualgen-15 NO PG for at least four (4) months without satisfactory results.

    ✔ Free of Propylene Glycol (PG or PPG): PG is a major component used in other minoxidil hair growth products (such Kirkland minoxidil, DS laboratory) as a delivery vehicle. It is not used in this product to avoid any scalp irritation such as scalp itchiness and/or inflammation. Glycerin is used as the delivery vehicle. This product is called Dualgen-15 NO PG Plus to be differentiated from the other product called DualGen-15 With PG Plus that has same effective ingredients but compounded using propylene glycol as the delivery vehicle.

     

DOES TOPICAL FINASTERIDE WORK?
  •  

    Dr. Richard Lee made a cocktail with minoxidil and finasteride solution (not cream) 10 years ago. According to his clinic experience, it works a lot better than minoxidil alone at the same strength. The results are similar or even better than using the same strength of minoxidil together with oral finasteride pill (1mg) while with less side effects.

     

    In the 7th World Congress on Hair Research, a Dutch research group reported the effect of topical and oral administration of finasteride on  DHT levels in scalp and serum. The results are shown in the Table below. It shows that when 1 mg of topical finasteride (once a day) controls DHT level in scalp more effectively than 1 ml of oral finasteride. It reduces DHT level in scalp by 71% while the oral finasteride only decreases by 51%.  Meanwhile, both administrations decrease DHT level in serum by almost the same degree (~70%). This is understandable, as the topical finasteride is applied to scalp directly and finasteride concentration in scalp is expected to be higher than when the same amount of finasteride is administrated orally. This study also suggests if you get side effect from oral finasteride, you will most likely get side effect from topical finasteride.

     

     

     

    DHT level Change in Scalp (decreased by)

    DHT level Change in serum (decreased by)

    1 mg topical Finasteride

    Once a day (q.d) (N=6)

    71%

    69.3–74.0%

    Twice a day (b.i.d)

    (each time is 0.5mg) (N=6)

    47%

    67.6–80.4% 

    Finasteride oral Pill

    Once a day (N=6)

    51%

    69.7–76.1%

     

    (see the details of this study below, study 1)

     

    There are some other studies that show similar conclusion. In 2012, a Thailand group compared the efficacy and safety of the 24 weeks application of 3% minoxidil lotion (MNX) versus combined 3% minoxidil and 0.1% finasteride lotion (MFX) in men with AGA. Results show the MFX group had significantly greater improvement in than the MNX group in the hair regrowth, and no side effect was reported (see the details of this study below, study 2).

     

     

    In 2009, an Iran group compared the therapeutic effects of topical finasteride gel and tablet in treatment of the male pattern hair loss, and found that therapeutic effects of both finasteride gel and finasteride tablet were relatively similar to each other ( (see the details of this study below, study 3).

     

    Interestingly, the results also shows that when you applied 0.5 mg topical finasteride twice a day (total amount is 1mg) is actually less effective in controlling DHT level in scalp, compared to applying 1mg of topical finasteride once a day. The former decrease the DHT level in scalp by 47%, while the latter by 71%.

  • ✔ STUDY 1:

    Pharmacodynamic of P-3074 (finasteride 0.25% topical solution) in subjects with androgenetic alopecia

    M Caserini1, R Palmieri1, M Radicioni2 and E Terragni1Polichem S.A., Lugano, Switzerland and 2Cross Research S.A., Arzo, Switzerland

    Abstract

     

    A new proprietary topical formulation, P-3074, containing finasteride 0.25% as active ingredient and hydroxypropyl-chitosan (HPCH) as film-forming agent, was developed for androgenetic alopecia. The present study was aimed at investigating the pharmacodynamic profile of finasteride in terms of dihydrotestosterone (DHT) concentrations in the scalp and in serum after multiple topical application of P-3074 or oral finasteride intake in subjects with androgenetic alopecia. Eighteen healthy men were randomly allocated to P-3074 or oral treatment after providing written informed consent. Twelve volunteers applied P-3074 topical solution for 7 days: six subjects once daily (o.d.) in the morning and the others twice daily (b.i.d.) in the morning and in the evening. The third group of six volunteers was administered 1mg oral finasteride once daily in the morning for 1 week. Scalp (vertex) biopsies were collected at baseline and 6hours after last dose administration, while serum samples were collected at baseline, before last administration, and 6 and 12hours after the last multiple dose. A marked decrease in scalp DHT levels was observed: by 47.22% with P-3074 b.i.d., from 1.91 (±0.54) to 1.01ngml−1 (±0.39), by 71.20% with P-3074 o.d., from 1.52 (±0.41) to 0.44ngml−1 (±0.08), and by 51.11% with the oral formulation, from 1.39 (±0.25) to 0.68ngml−1 (±0.34). Serum DHT was reduced by 69.3–74.0% with P-3074 b.i.d., 67.6–80.4% with P-3074 o.d., and 69.7–76.1%with the oral formulation. These results showed a similar inhibition of serum DHT after 1 week of finasteride administration with the three dose regimens and were consistent with the results obtained in a previous P-3074 PK study. These findings show that DHT concentration in the scalp, after 7-day treatment course of P-3074 o.d., was more reduced (about 40%) than after 1mg oral finasteride administration for the same treatment period.

     

    ✔ STUDY 2:

    J Med Assoc Thai. 2012 Oct;95(10):1312-6.

    Efficacy and safety of 3% minoxidil versus combined 3% minoxidil / 0.1% finasteride in male pattern hair loss: a randomized, double-blind, comparative study.

    Tanglertsampan C.

    Abstract

    BACKGROUND:

     

    Topical minoxidil and oral finasteride have been used to treat men with androgenetic alopecia (AGA). There are concerns about side effects of oral finasteride especially erectile dysfunction.

    OBJECTIVE:

    To compare the efficacy and safety of the 24 weeks application of 3% minoxidil lotion (MNX) versus combined 3% minoxidil and 0.1% finasteride lotion (MFX) in men with AGA.

    MATERIAL AND METHOD:

    Forty men with AGA were randomized treated with MNX or MFX. Efficacy was evaluated by hair counts and global photographic assessment. Safety assessment was performed by history and physical examination.

    RESULTS:

    At week 24, hair counts were increased from baseline in both groups. However paired t-test revealed statistical difference only in MFX group (p = 0.044). Unpaired t-test revealed no statistical difference between two groups with respect to change of hair counts at 24 weeks from baseline (p = 0.503). MFX showed significantly higher efficacy than MNX by global photographic assessment (p = 0.003). There was no significant difference in side effects between both groups.

    CONCLUSION:

    Although change of hair counts was not statistically different between two groups, global photographic assessment showed significantly greater improvement in the MFX group than the MNX group. There was no sexual side effect. MFX may be a safe and effective treatment option.

     

    ✔ STUDY 3:

    ndian J Dermatol Venereol Leprol. 2009 Jan-Feb;75(1):47-51.

    Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia.

    Hajheydari Z1, Akbari J, Saeedi M, Shokoohi L.
     

    Abstract

    BACKGROUND:

    Finasteride, a type II-selective 5alpha-reductase inhibitor, as a causative agent of decreasing dihydroxy testosterone (DHT) level, is effective in the treatment of male androgenic alopecia.

    AIM:

    We compared the local and oral finasteride in the treatment of androgenic alopecia.

    METHOD:

    This is a double blind, randomized clinical trial study of 45 male patients, who were referred with alopecia to the private clinics and departments in Boo-Ali Sina Hospital, in Sari. Patients with male androgenic alopecia were selected according to the history and physical examinations. The patients were randomly divided into two: topical finasteride (A) and oral finasteride (B) groups. Topical finasteride group (A) received a topical gel of 1% finasteride and placebo tablets, while the oral finasteride group (B) received finasteride tablets (1 mg) and gel base (without drug) as placebo for 6 months. The patients were followed by clinical observation and recording of side effects prior to the treatment and at the end of first week, and then by a monthly follow-up. The size of bald area, total hair count, and terminal hair were studied. Data were analyzed by descriptive and Chi-square statistical test.

    RESULTS:

    The mean duration of hair loss was 18.8+/-23.10 months. Each month the terminal hair, size of bald area and hair count between the two groups were compared. There were no significant differences between the two groups as a viewpoint of hair thickness, hair counts and the size of bald area. Serial measurements indicated a significant increase in hair counts and terminal hair counts between the two groups.

    CONCLUSIONS:

    The results of this study showed that the therapeutic effects of both finasteride gel and finasteride tablet were relatively similar to each other.

     

     

Special Notes
  • Please be advised that there are two versions of Dualgen-15 Plus:  one is DualGen-15 NO PG Plus, the other is DualGen-15 With PG Plus

    1. If you are not allergic to propylene glycol, it is recommended to use DualGen-15 With PG Plus that is slightly less greasy than DualGen-15 NO PG Plus.
    2. If you would like to buy this product without finasteride due to the concern over the possible side effects caused by finasteride (less than 2% users may experience decreased libido or sex drive), please check out Dualgen-15 NO PG.

     

  •  If you never used our Dualgen-15 NO PG (free of finasteride), you are recommended to try Dualgen-15 NO PG first. The addition of finasteride to Dualgen-15 NO PG makes it stronger in blocking DHT. However, the presence of finasteride may cause sexual side effect such as decreased libido or sex drive in some people (estimated to less than 2% users). Click here to see our Dualgen-15 NO PG.

     

  • No need to take Finasteride pill with this product: If you are currently taking 1mg finasteride pill a day, you don't need to continue to take the pill if you use this topical finasteride product. The amount of finasteride in each mL is 1 mg.

     

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